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WEIGHT LOSS, SYNDROME X, DIABETES, PCOS WELLNESS NEWS

04/10/16 - Are you pre-diabetic? 46% of California adults are, UCLA study finds

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09/01/14 -

Low-carb vs. low-fat diets 


1. Low-carb trumps low-fat for weight loss and cardiovascular risk

2. Rise in obesity is a substantial contributor to increased prevalence of diabetes

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09/23/12 -

Chocolate can create same high as opium: Links found between obese people and drug addicts

  • Study looked at natural brain chemical of enkephalin
  • It's an endorphin with similar properties to opium


Read more: http://www.dailymail.co.uk/health/article-2206310/Chocolate-create-high-opium-Links-obese-people-drug-addicts.html#ixzz27JWfsmpT 


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05/12/10 -

Avandia and FDA Both Subject of Severe Criticism at Congressional Hearing

Sue Hughes

May 11, 2010 (Washington DC) — Both the diabetes drug rosiglitazone (Avandia, GlaxoSmithKline) and the way the FDA has handled concerns about it took another severe battering at a recent US Congressional hearing of the committee that has jurisdiction over the FDA.

The House Appropriations Subcommittee on Agriculture, Rural Development, Food and Drug Administration, and Related Agencies met on April 28 to discuss the report on rosiglitazone released in February by the Committee on Finance of the US Senate.

The report [1], by Sens Max Baucus (D-MT) Charles Grassley (R-IA), concluded that there are "serious health risks associated with Avandia." It also criticized the structure of the FDA, particularly the fact that those who make decisions about drug approvals are the same experts who must later oversee drug safety.



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05/04/10 -

Type 2 Diabetes and TCF7L2 - Author: Ali Torkamani, PhD, Assistant Faculty, Research, Scripps Genomic Medicine and Assistant Professor of Molecular and Experimental Medicine, Scripps Research Institute
 

TCF7L2 variants have been associated with type 2 diabetes in multiple ethnic groups.1,2,3,4,5,6,7 Specific associated variants increase risk of type 2 diabetes 1.5-fold in heterozygotes and 2.41-fold in homozygotes, corresponding to a population attributable risk of 21%. This makes TCF7L2 variants the strongest known genetic risk factor for type 2 diabetes.8

TCF7L2 is a transcription factor and key component of the Wnt signaling pathway, and is involved in the development of a wide variety of cell lineages and organs.9 Potential mechanisms by which TCF7L2 variants influence type 2 diabetes include its role in adipogenesis, myogenesis, and pancreatic islet development, as well transcription of the genes for proglucagon and the glucagon-like-peptides GLP-1 and GLP-2, which play a role in post-prandial insulin secretion.10 Additionally, TCF7L2 polymorphisms have been associated with impaired insulin secretion, glucose production, and glucose tolerance via direct effects on pancreatic islet beta-cells.11,12 Thus, while the specific mechanism driving the development of type 2 diabetes remains unclear, there is sufficient evidence to demonstrate that TCF7L2 variants strongly predict the development of type 2 diabetes and/or the progression to diabetes from impaired glucose tolerance.12,13



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04/09/10 - The unique endocrine milieu of the fetus. D A Fisher -- Table II summarizes in tabular form the major features of the fetal endocrine milieu discussed in the foregoing pages. The mammalian fetus develops in an environment where respiration, alimentation, and excretory functions are provided by the placenta. Fetal tissue metabolism is oriented largely to anabolism; body temperature is modulated by maternal metabolism, and fetal tissue thermogenesis is maintained at a basal level. Tissue and organ growth appear to be regulated by growth factors which probably function by autocrine or paracrine mechanisms during most of gestation (72, 146-148). In this milieu conventional endocrine control systems are largely redundant, and other transient systems more appropriate to the intrauterine environment have evolved. We have developed some insights into these systems, but much more information is necessary before we can truly understand this fascinating environment.

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06/15/09 - Obesity ops 'raise fracture risk' -- People who have obesity operations, such as gastric bypasses or banding, double their risk of suffering fractures, US research suggests. Researchers for the Mayo Clinic in the US reviewed nearly 100 surgical cases spanning 21 years for their study. They found a fifth of patients suffered fractures - twice the rate typical for their age - with most breaks occurring in the bones of the hands and feet.

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06/15/09 - Obesity ops 'raise fracture risk' -- People who have obesity operations, such as gastric bypasses or banding, double their risk of suffering fractures, US research suggests. Researchers for the Mayo Clinic in the US reviewed nearly 100 surgical cases spanning 21 years for their study. They found a fifth of patients suffered fractures - twice the rate typical for their age - with most breaks occurring in the bones of the hands and feet.

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