Diet soda linked to higher leukemia risk

Dental records can identify osteoporosis risk years before condition develops

By ROGER DOBSON

HU discovery could improve osteoporosis drugs

Barin-to-bone research on mice injected with rabies proves existence of parasympathetic responses in skeleton.

New System for Kidney donations could change how organ is allocated

Posted by david on Sep 22nd, 2012 // No Comments

AAEM -- USDA Completely Deregulates Genetically Engineered Alfalfa-It is Time to Demand Congressional Hearings! (Action Alert)

MycoD2 NEW Nutraceutical Research and Wellness Launch:

This Video Report Interview of Dr Marvin Hausman MD re launch of the amazing new breakthrough of MycoD2 to protect brain, heart and vascular systems with Agaricus Blazei mushroom and proprietary UV activated Vitamin D2.

S 510 is hissing in the grass

Obama White House Hands Out 111 Obamacare Waivers- Hides It From Public (Video)

Posted by Jim Hoft on Sunday, November 14, 2010, 3:09 AM

A genuine "elixir of life" that can hold death at bay has been discovered by scientists.

Coconut Oil and Alzheimer’s Disease

October 5, 2010

Type 2 Diabetes and TCF7L2 - Author: Ali Torkamani, PhD, Assistant Faculty, Research, Scripps Genomic Medicine and Assistant Professor of Molecular and Experimental Medicine, Scripps Research Institute
 

TCF7L2 variants have been associated with type 2 diabetes in multiple ethnic groups.^{1,2,3,4,5,6,7} Specific associated variants increase risk of type 2 diabetes 1.5-fold in heterozygotes and 2.41-fold in homozygotes, corresponding to a population attributable risk of 21%. This makes TCF7L2 variants the strongest known genetic risk factor for type 2 diabetes.⁸

TCF7L2 is a transcription factor and key component of the Wnt signaling pathway, and is involved in the development of a wide variety of cell lineages and organs.⁹ Potential mechanisms by which TCF7L2 variants influence type 2 diabetes include its role in adipogenesis, myogenesis, and pancreatic islet development, as well transcription of the genes for proglucagon and the glucagon-like-peptides GLP-1 and GLP-2, which play a role in post-prandial insulin secretion.¹⁰ Additionally, TCF7L2 polymorphisms have been associated with impaired insulin secretion, glucose production, and glucose tolerance via direct effects on pancreatic islet beta-cells.^11,12 Thus, while the specific mechanism driving the development of type 2 diabetes remains unclear, there is sufficient evidence to demonstrate that TCF7L2 variants strongly predict the development of type 2 diabetes and/or the progression to diabetes from impaired glucose tolerance.^12,13