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DR BILL'S PRODUCTS: NUTRIMEDS
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MALIGNABLOCK 120 capsules $97.95
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Broccoli sprout concentrate from Johns Hopkins University, used for protect cellular tissue and treating abnormal cells. Over 300 published studies on this ingredient being used.

Clinical Applications

MalignaBlock

Discussion

Researchers at Johns Hopkins University, with a grant from NIH received numerous US patents on sulforaphane glucosinolate (SGS), the active ingredient in MalignaBlock. The patents relate to preparation and properties of this glucosinolate. The major property patented is the role of SGS as a potent chemopreventive substance. In accordance with one of the patents, Research Manufacturer of MalignaBlock sought and received from Brassica

Protection Products, the commercial licensee of Johns Hopkins University a license to distribute this extraordinary formula.

Sulforaphane an isothiocyanate is a compound that was isolated and identified in 1992 by researchers at Johns Hopkins University School of Medicine as the likely reason for the well-documented epidemiological evidence that diets rich in cruciferous vegetables, especially broccoli, may reduce the risk of cancer. Sulforaphane glucosinolate (SGS) is the precursor of sulforaphane, present in cruciferous vegetables and especially rich in certain varieties of broccoli and broccoli sprouts. Glucosinolates are plant secondary metabolites. That is, when the plant is cut or chewed the glucosinolates are enzymatically broken down into sulforaphane and other biologically-active compounds. The greatest amount of sulforaphane glucosinolate is present when broccoli plants are just two or three days old. Broccoli sprouts (as they are called at this growth stage) contain about 250 mgs of sulforaphane glucosinolate per 100 grams.

Isothiocyanates are of particular interest due to their role in chemoprotection. More than 200 publications throughout the world have underscored the significance of sulforaphane glucosinolates. The observed pattern of chemoprotection indicates that the breakdown products of glucosinolates may decrease the amount of DNA damage and cell proliferation, as well as block the processes that inhibit apoptosis and stimulate unregulated cell growth. These compounds are considered monofunctional modulators. They upregulate Phase 2 mammalian detoxification enzymes without upregulating Phase 1, carcinogen-producing enzymes. SGS may be referred to as an indirect antioxidant because the body's own Phase 2 detoxication enzymes provide broad-spectrum antioxidant activity that may last for several days after the SGS has been consumed. Animal studies show SGS protects multiple organs from chemically-induced cancers.

Most of the chemoprotection studies have used natural preparations containing the amount of SGS equivalent to that in a single capsule of MalignaBlock SGS?. Unlike direct antioxidants, such as vitamins C and E, it is very unlikely that SGS could become a prooxidant.

The ability of sulforaphane to induce Phase 2 enzymes may also account for its possible benefit for arthritic joints. These enzymes seem to prevent the activation of the inflammatory COX-2 enzyme.

Clinical Applications

MalignaBlock

Discussion

Researchers at Johns Hopkins University, with a grant from NIH received numerous US patents on sulforaphane glucosinolate (SGS), the active ingredient in MalignaBlock. The patents relate to preparation and properties of this glucosinolate. The major property patented is the role of SGS as a potent chemopreventive substance. In accordance with one of the patents, NutriMeds sought and received from Brassica Protection Products, the commercial licensee of Johns Hopkins University a license to distribute this extraordinary formula.

* Chemoprotective

* Protection against G.I. Damage by H Pylori

* Supports Eye Health

* Blood Pressure, CV Inflammation

* Joint Health

Patented and licensed from Brassica Protection Products and Johns Hopkins

University under US patents:5,725,895; 5,968,505; 5,968,567; 6,177,122, and 6,242,018

MalignaBlock is manufactured and a Federal Drug Registered and State Board Pharmacy cGMP laboratory 1. SGS? Fact Sheet, Brassica Protection Products LLC Baltimore, MD

2. Shapiro TA, Fahey JW, Wade KL, Stephenson KK, Talalay P. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans. Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):501-8.

3. Fahey JW, Zhang Y, Talalay P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci 1997;94:1036772.

4. Nestle M. Broccoli sprouts as inducers of carcinogen-detoxifying enzyme systems: clinical, dietary, and policy implications. Proc Natl Acad Sci 1997;94:1114951 [review].

5. Zhang Y, Kensler TW, Cho CG, Posner GH, Talalay P. Anticarcinogenic activities of Sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proc. Natl. Acad. Sci. USA, 1994; Apr91:3147-3150.

6. Zhang Y, Talalay P, Cho CG, Posner G. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc. Natl. Acad. Sci. USA, 1992; Mar 89:2399-2403

7. Jackson SJ, Singletary KW. Sulforaphane inhibits human MCF-7 mammary cancer cell mitotic progression and tubulin polymerization. J Nutr. 2004 Sep;134(9):2229-36.[ PMID: 15333709]

8. Chiao JW, Wu H, Ramaswamy G, Conaway CC, Chung FL, Wang L, Lui D. Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenographs by apoptosis and cell cycle arrest. Carcinogenesis 2004; 25(8):1403-1408 [PMID: 15016658]

9. Fahey JW, Haristoy X, Dolan PM, Kensler TW, Scholtus I, Stephenson KK, Talalay P, Lozniewski A. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci USA. 2002 May 28;99(11):7610- [PMID: 12032331]

10. Yanaka, A. Broccoli Sprouts Relieve Gastritis in H. pylori Patients: May Help Prevent Gastric Cancer (Abstract #3442) American Institute for Cancer Research Annual Meeting. Baltimore, MD, Poster Session: 7:30 a.m. Nov 2, 2005

11. Gao X, Talalay P. Induction of Phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage . Proc Natl Acad Sci USA 2004 July 101 (28): 10446-10451 [www.pnas.org/cgi/doi/10.1073/pnas.0403866101]

12. Wu L, et al. Dietary approach to attenuate oxidative stress, hypertension, and inflammation on the cardiovascular system. 2004, May 101(18):7094- 7099 [www.pnas.org/cgi/doi/10.1073/pnas.0402004101

13. Healy, Z. Proceedings of the National Academy of Sciences 2005, Sept: 102(39): 14010-14025,

14. http://www.broccosprouts.com/health/sgsfactsheet.htm {Accessed 11.4.05}

15. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolizing activity. Cancer Lett 1997;114:169?70.

References

Dosing

At the time of this writing there have not been any side effects or drug interactions reported. However, since sulforaphane does interact with drug detoxifying enzymes, individuals taking prescription drugs deserve close evaluation and supervision.

Contraindications

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Sulforaphane has been found to be a potent bacteriostatic agent against three reference strains and 45 clinical isolates of H. pylori, irrespective of their resistance to conventional antibiotics. SGS? activates antioxidant enzymes in the gastric mucosal that prevent H. pylori DNA-induced damage.

HPMC hydroxypropylmethylcellulose, the highly purified, hypo-allergenic, non-GMO form of cellulose that is physiologically inert constitutes the capsules in which MalignaBlock SGS is contained.

Prelude

Why is cancer on the rise? Are you concerned about getting cancer? What can you do to protect yourself? Researchers from acclaimed institutions like: Johns Hopkins, Stanford, Rutgers, UCLA, Columbia University, Pittsburgh Cancer Institute, Roswell Cancer Institute, The University of Georgia, Oregon State University, The University of Washington and The University of South Carolina have all published amazing clinical research on a compound called sulforaphane glucosinalate or SGS. This compound has been researched in a variety of cancers including; Breast, ovarian, prostate, bone, brain, bladder, liver, lung, and gastric. It has also been found to be supportive in a variety of other conditions associated with aging and cell death.

History of Discoveries

It has been widely accepted for decades that a diet rich in fruits and vegetables is important for good health. It is safe to say that everyone has a memory of being told to, "Eat your vegetables. They are good for you!" But why is a diet rich in fruits and vegetables good for us? Extensive epidemiological evidence has been established in the scientific community with very little doubt that a diet rich in fruits and vegetables is associated with large and dose-related reduction in the risk of developing cancer. Yet these observations do not answer the fundamental question of how such a diet can protect against cancer. Research scientists at Johns Hopkins University School of Medicine in Baltimore have focused on cancer research using natural phytochemicals and achieving early protection against cell damage.

Reducing Risk of Some Cancers with Diet

With 10.3 million new cancer cases diagnosed each year worldwide, medical investigators are taking a closer look at how diet may help reduce cancer risk. As many as two-thirds of these cancers may be caused by diet and lifestyle factors. A number of studies indicate that diets rich in fruits and vegetables contribute to decreased risk of many types of cancers. Researchers at Johns Hopkins University School of Medicine have investigating specific phytochemicals found in cruciferous vegetables that may serve as weapons against cancer and other diseases.

During the past eight years, in the culmination of decades of scientific research, researchers at Johns Hopkins University School of Medicine made a series of breakthrough discoveries in this area. Their scientific findings relating to SGS (sulforaphane glucosinolate), a compound found in broccoli, may help to explain the widely recognized scientific evidence indicating that populations consuming a diet rich in fruits and vegetables, and especially cruciferous vegetables such as broccoli, have a reduced risk of developing several types of cancers. Now, other institutions around the world have also begun to conduct research on the role of SGS in cancer prevention and protection. More than 300 scientific studies point to an antioxidant found in broccoli sprouts, sulforaphane glucosinolate (SGS), as a factor in preventing multiple diseases, including several types of cancer, high blood pressure, macular degeneration and stomach ulcers. Now a new study shows the naturally occurring antioxidant SGS may help reduce cholesterol levels in a matter of days.

High Levels of SGS Found in Broccoli Sprouts

The researchers discovered that young broccoli sprouts, grown from the seeds of certain varieties of broccoli, can be produced under carefully standardized conditions to contain consistently high concentrations of SGS. Researchers found that, on average, one ounce of these special sprouts provided as much SGS as 1 1/4 pounds (20 ounces) of mature, cooked broccoli (20 times the concentration). In addition there is a new delivery system you can achieve 30 mg of SGS, equal to 1 ? pounds of broccoli from 1 capsule of concentrated sulforaphane glucosinalates.

Chemoprotection

Johns Hopkins initial research targeted the potential chemoprotective effects of certain vegetable varieties. "Chemoprotection is a deliberate effort to increase the body's defense systems against chemicals, including carcinogens, that can lead to disease," according to Dr. Talalay, Chief researcher at Johns Hopkins University. "Chemoprotection may lower a person's risk of developing cancer by building up the body's own defense." Dr. Talalay's strategy of chemoprotection takes advantage of the body's Phase 2 detoxification enzymes that help neutralize cancer-causing chemicals, as well as free radicals, before they can damage DNA and initiate the development of cancer. As part of this research strategy Johns Hopkins University isolated and identified sulforaphane, a natural compound found in broccoli. They found sulforaphane to be the most potent booster of Phase 2 enzymes, which stimulate the ability of animal cells to protect against disease.

Antioxidant Activity of Sulforaphane

Sulforaphane exists in cruciferous vegetables such as broccoli and cabbage. In its precursor form, sulforaphane glucosinolate (SGS) functions as an indirect antioxidant. As such, this compound does not directly neutralize free radicals as do direct antioxidants like vitamins E and C and beta-carotene. Indirect antioxidants induce (or boost) the activity of the Phase 2 detoxification enzymes. According to Dr. Talalay, "These enzymes act as a defense mechanism, triggering broad spectrum antioxidant activity that neutralizes many free radicals, cycling over and over again before they can cause the cell damage that may cause mutations, leading to cancer." Furthermore, the effects of these indirect antioxidants remain even after they have left the body - unlike direct antioxidants, which neutralize only one molecule of a radical at a time, and are destroyed in the process. The indirect antioxidant effects are long-lasting, triggering an ongoing process that continues to be effective and may last for 2 days.

New science is showing that certain foods, like broccoli sprouts, contain compounds that are able to selectively boost only the Phase II enzymes. These compounds, such as sulforaphane, are called monofunctional inducers. Thus, it is becoming at least theoretically possible to find a diet that strikes a perfect balance, producing two desirable effects at the same time: inhibiting Phase I enzymes, which minimizes the excess number of carcinogens produced, and increasing Phase II enzymes, which makes the body better able to defend itself from cancer.

The Latest Cancer Research

Most recently, researchers from the U.S. and Europe have further examined the effects of SGS in cancer models. There have been more than 100 published clinical trials in the last 2 years alone.

* Sulforaphane may be a promising therapeutic approach for the treatment of cancers, including those characterized by increased inflammation. (Cancer Lett. 2006 Feb 28;233(2):208-18 Oregon State University).

* There was a 95.5% inhibition of lung tumor nodule formation and a 94.06 increase in lifespan or tumor bearing animals. These findings suggest that sulforaphane reduced the invasion of melanoma cells thereby inhibiting lung metastasis. (Life Sci, 2006 May 22;78(26):3043-50)

* The results of the present study indicate that sulforaphane induced cell death in prostate cancer cells. (J Biol Chem 2005 May 20; 280(20):19911-24 University of Pittsburgh Cancer Institute)

* Sulforaphane is a potent and promising naturally occurring dietary cancer chemoprotective compound that excerpts it cancer protective effects by the induction of phase 2 detoxification. (Cancer Lett. 2006 Mar 2: Rutgers University)

* Sulforaphane potently induces phase 2 enzymes in bladder tissues and should be investigated as a bladder cancer preventive agent. (BMC Cancer 2006 Mar 15;6:63 Stanford School of Medicine)

* Sulforaphane is known to induce phase 2 detoxification enzymes, disrupt cancer cells, and trigger cell cycle arrest in breast and colon cancer cells . (Vascul. Pharmacol. 2006 Jul 14 University of Georgia)

* We observed potent antiproliferative effects of sulforaphane on human ovarian cancer cell lines. (Mol Cancer Ther. 2007 Jan;6(1):334-4)

* Our data indicate that sulforaphane derived form broccoli suppress the invasive potential of human MDA-MB-231 breast cancer cells in vitro. The inhibitory effects observed in the current study may contribute to the suppression of carcinogenesis by diets high in cruciferous vegetables. (Toxicol Appl Pharmacol. 2005 Dec 1;209(2):105-13.)

* Researchers have discovered that sulforaphane can halt human breast cancer cells in their tracks and have identified a new mechanism of action for the compound.? (Drug Discov Today. 2004 Nov 1;9(21):908)

* Sulforaphane (SFN) is a biologically active phytochemical found abundantly in broccoli. SFN has been promoted as a putative chemopreventive agent to reduce cancer, and most studies have associated its anti-cancer effects with the induction of phase II xenobiotic metabolism enzymes. (Mol Pharmacol. 2007 Jan;71(1):220-9. Epub 2006 Oct 6. University of Washington)

* In conclusion, the results show, for the first time, that chemopreventive agents such as sulforaphane regulate different set of genes involving apoptosis, cell growth/maintenance and inflammation in the small intestinal polyps of ApcMin/+ mice, which could contribute to the overall chemopreventive pharmacological effects. (Biopharm Drug Dispos. 2006 Dec;27(9):407-20 Rutgers Univ.)

* Our results indicated activation of multiple molecular mechanisms for apoptosis in glioblastoma cells following treatment with sulforaphane. (Neuroscience. 2006 Sep 1;141(3):1265-80. Epub 2006 Jun 12. Medical University of South Carolina)

Conclusion

The Johns Hopkins strategy and discoveries are consistent with what many epidemiologic studies have shown: Many cancers may be related to lifestyle or extrinsic factors and are, therefore, in principle, preventable. Johns Hopkins researchers continue to focus on SGS and other compounds from edible plants that may have potential chemoprotective effects.

Where can you get MagniBlock Sulforaphane Glucosinalates

The Johns Hopkins University has partnered with NutriMeds, one of the leading professional nutraceutical companies in the industry to market sulforaphane. Sulforaphane SGS is marketed under the name MagniBlock SGS by and can be purchased exclusively through health care providers nationwide. In addition MagniBlock SGS can be ordered by calling (888)212-8871. Dosage for MagniBlock ranges between 1-8 capsules daily depending upon condition.

Instructions/How to Use:

Take one capsule daily or as directed by your healthcare practitioner.

Ingredients:

Sulfurophane glucosinolate 30 mg per capsule

Cautions/Warnings:

At the time of this writing there have not been any side effects or drug interactions reported. However, since sulforaphane does interact with drug detoxifying enzymes, individuals taking prescription drugs deserve close evaluation and supervision.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Conditions:

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