••Regulates Microbial Activity in the GI Tract
••Supports Healthy Immune Function
••Supports a Healthy Inflammatory Response
••Promotes Mucous Membrane Health
Many plants have been used throughout history for their ability to influence microbial activity and support healthy immune function. These traditional therapies of natural origin can be used safely and effectively without many of the adverse side effects associated with new, synthetic molecules. Potency is an important aspect in achieving the benefits imparted by an herbal supplement. The herbs in BerberStatin are concentrated to a 4:1 end ratio. This means that the equivalent raw herb conversion is 4 kg raw herb to 1 kg of extracted material. All actives are provided in easy-dissolving vegetarian capsules.
Berberis aquifolium (Oregon grape) Berberine is a plant alkaloid derived from a variety of herbs, including Oregon grape root. This phytochemical constituent has a long history of use in Chinese and Ayurvedic medicine owing to its effectiveness and safety. Berberine extracts have demonstrated significant ability to influence the activity of a variety of organisms that have the potential to negatively affect human health.[1-3] Mechanisms of action may include effects on organism adhesion and intracellular invasion, metabolic activity, maturation, and enterotoxin formation. In an experimental model, berberine was also found to modulate the MAPK (mitogen-activated protein kinase) pathway, which had been manipulated by parasites in a manner that helped ensure their survival. Berberine has even been shown to act synergistically with some microbe-targeting medications. Not only does berberine show inhibitory effects, but it can also address the intestinal secretion of water and electrolytes induced by certain organism toxins, thereby supporting healthy stool formation. Furthermore, it may reduce smooth muscle contraction and intestinal motility, and delay intestinal transit time. Both in vitro and animal research suggest that berberine can moderate inflammation through its effects on COX-2 protein.
Myrica cerifera (bayberry) The root bark and berry of bayberry have been traditionally used as an astringent and circulatory stimulant. Like the berry, the root bark contains tannin constituents that are responsible for its astringent action.[5,6] Astringent herbs are traditionally used to stop sweating, control the bowels, control essence (the body’s reproductive and regenerative substance), and hold in urine, as well as to stop leukorrhea, bleeding, and coughing. They are indicated in cases with weakness and other secondary effects of fighting pathogens—especially those affecting the body’s natural defenses, the GI tract, and hydration. As a circulatory stimulant, bayberry helps to increase body energy levels and supports toxin elimination. Myricitin, a flavonoid isolated from bayberry, is a potent antioxidant that may help moderate the inflammatory response and possibly protect colon cells.
Citrus x paradisi (grapefruit) The seed extract of grapefruit, commonly known as GSE, is widely used as an oral supplement to address microbial activity. It has also been used in rinse and topical forms to clean mucous membranes and skin. In agricultural and food processing, grapefruit seed extract is used as a bactericide and fungicide, a mold inhibitor, an antiparasitic for animal feeds, a food preservative and antioxidant, and a water disinfectant. GSE contains high amounts of protective, free-radical–eliminating antioxidants and phytonutrients called bioflavonoids—including hesperidin, a well-known natural immune-system stimulator that also influences inflammatory pathways.[8,9]
Zinc The supportive effects of zinc on immunity and microbial balance are well documented.[10,11] Zinc ions are thought to work directly in the GI tract, affecting microbial activity therein. Immune cells, due to their high rate of proliferation and differentiation, need a constant and sufficient supply of zinc. Although further study is needed, zinc supplementation also shows promise in its ability to support healthy stool formation. In this formula, zinc is provided as Albion® TRAACs zinc glycinate chelate for optimal absorption and utilization.
BerbeStatin features a concentrated 4:1 extract of Oregon grape root, which supplies berberine—a plant alkaloid that influences the activities of microorganisms in the gastrointestinal tract, supports immune function, and may influence the inflammatory response. The 4:1 extracts of bayberry bark and grapefruit seed complement the actions of berberine to regulate microbial activity, stimulate circulation, and promote mucus membrane health. Zinc is included in this formula for its immune-supportive effects.*
1. Vuddanda PR, Chakraborty S, Singh S. Berberine: a potential phytochemical with multispectrum therapeutic activities. Expert Opin Investig Drugs. 2010 Oct;19(10):1297-307. [PMID: 20836620]
2. Yu HH, Kim KJ, Cha JD, et al. Antimicrobial activity of berberine alone and in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus. J Med Food. 2005 Winter;8(4):454-61. [PMID: 16379555]
3. Rohrer U, Kunz EM, Lenkeit K, et al. Antimicrobial activity of Mahonia aquifolium and two of its alkaloids against oral bacteria. Schweiz Monatsschr Zahnmed. 2007;117(11):1126-31. [PMID: 18072463]
4. Saha P, Bhattacharjee S, Sarkar A, et al. Berberine chloride mediates its anti-leishmanial activity via differential regulation of the mitogen activated protein kinase pathway in macrophages. PloS One. 2011 Apr 5;6(4):e18467. [PMID: 21483684]
5. Myrica cerifera. Withlacoochee Permaculture Guild. http://wcpermaculture.org/plants/myrica-cerifera. Accessed August 2, 2011.
6. Grieve M. Bayberry. A Modern Herbal. Botanical.com. http://botanical.com/botanical/mgmh/b/bayber20.html. Accessed August 2, 2011.
7. Asano N, Kuno T, Hirose Y, et al. Preventive effects of a flavonoid myricitrin on the formation of azoxymethane-induced premalignant lesions in colons of rats. Asian Pac J Cancer Prev. 2007 Jan-Mar;8(1):73-76. [PMID: 17477776]
8. Lee YR, Jung JH, Kim HS. Hesperidin partially restores impaired immune and nutritional function in irradiated mice. J Med Food. 2011 May;14(5):475-82. [PMID: 21434774]
9. Manthey JA. Biological properties of flavonoids pertaining to inflammation. Microcirculation. 2000;7(6 Pt 2):S29-34. [PMID: 11151968]
10. Puertollano MA, Puertollano E, de Cienfuegos GÁ, et al. Dietary antioxidants: immunity and host defense. Curr Top Med Chem. 2011;11(14):1752-66. [PMID: 21506934]
11. Knoell DL, Liu MJ. Impact of zinc metabolism on innate immune function in the setting of sepsis. Int J Vitam Nutr Res. 2010 Oct;80(4-5):271-77.