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DR BILL'S PRODUCTS: NUTRIMEDS
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VEIN AWAY 60 capsules $34.95
Download Product Sheet
Common Uses:

VASCULAR VEIN ARTERY REJUVENATOR
References
1. Monograph. Diosmin. Altern Med Rev. 2004 Sep;9(3):308-11. [PMID: 15387721]
2. Lyseng-Williamson KA, Perry CM. Micronised purified flavonoid fraction: 
a review of its use in chronic venous insufficiency, venous ulcers and 
haemorrhoids. Drugs. 2003;63(1):71-100. [PMID: 12487623]
3. Pitsch F. Recent guidelines in chronic venous disease: the place of Daflon 
500 mg. Phlebolymphology. 2011;18:24-29. http://www.phlebolymphology.
org/2011/01/recent-guidelines-in-chronic-venous-disease-the-place-of-daflon-
500-mg/. Accessed October 12, 2012.
4. Bergan JJ, Schmid-Schönbein GW, Takase S. Therapeutic approach to chronic 
venous insufficiency and its complications: place of Daflon 500 mg. Angiology. 
2001 Aug;52 Suppl 1:S43-7. [ PMID: 11510596]
5. Smith PD. Neutrophil activation and mediators of inflammation in chronic 
venous insufficiency. J Vasc Res. 1999;36 Suppl 1:24-36. [PMID: 10474048]
6. Korthui RJ, Gute DC. Anti-inflammatory actions of a micronized, purified 
flavonoid fraction in ischemia/reperfusion. Adv Exp Med Biol. 2002;505:181-90. 
[PMID: 12083462]
7. Jean T, Bodinier MC. Mediators involved in inflammation: effects of Daflon 500 
mg on their release. Angiology. 1994 Jun;45(6 Pt 2):554-9. [PMID: 8203787]
8. Ramelet AA. Clinical benefits of Daflon 500 mg in the most severe stages of 
chronic venous insufficiency. Angiology. 2001 Aug;52 Suppl 1:S49-56. [PMID: 
11510597]
9. Laurent R, Gilly R, Frileux C. Clinical evaluation of a venotropic drug in man. 
Example of Daflon 500 mg. Int Angiol. 1988 Apr-Jun;7(2 Suppl):39-43. [PMID: 
3053942]
10. Tsouderos Y. Are the phlebotonic properties shown in clinical pharmacology 
predictive of a therapeutic benefit in chronic venous insufficiency? Our 
experience with Daflon 500 mg. Int Angiol. 1989 Oct-Dec;8(4 Suppl):53-9. 
[PMID: 2698902]
11. Le Dévéhat C, Khodabandehlou T, Vimeux M, et al. Evaluation of 
haemorheological and microcirculatory disturbances in chronic venous 
insufficiency: activity of Daflon 500 mg. Int J Microcirc Clin Exp. 1997;17 Suppl 
1:27-33. [PMID: 9477042]
12. Galley P, Thiollet M. A double-blind, placebo-controlled trial of a new venoactive flavonoid fraction (S 5682) in the treatment of symptomatic capillary 
fragility. Int Angiol. 1993 Mar;12(1):69-72. [PMID: 8376915]
13. Belcaro G, Cesarone MR, de Sanctis MT, et al. Laser Doppler and 
transcutaneous oximetry: modern investigations to assess drug efficacy in 
chronic venous insufficiency. Int J Microcirc Clin Exp. 1995;15 Suppl 1:45-9. 
[PMID: 8748889]
14. Coleridge-Smith P, Lok C, Ramelet AA. Venous leg ulcer: a meta-analysis of 
adjunctive therapy with micronized purified flavonoid fraction. Eur J Vasc 
Endovasc Surg. 2005 Aug;30(2):198-208. [PMID: 15936227]
15. Smith PC. Daflon 500 mg and venous leg ulcer: new results from a metaanalysis. Angiology. 2005 Sep-Oct;56 Suppl 1:S33-9. [PMID: 16193225]
16. Guilhou JJ, Dereure O, Marzin L, et al. Efficacy of Daflon 500 mg in venous leg 
ulcer healing: a double-blind, randomized, controlled versus placebo trial in 107 
patients. Angiology. 1997 Jan;48(1):77-85. [PMID: 8995348]
17. Jantet G. Chronic venous insufficiency: worldwide results of the RELIEF study. 
Reflux assEssment and quaLity of lIfe improvEment with micronized Flavonoids. 
Angiology. 2002 May-Jun;53(3):245-56. [PMID: 12025911]
18. Valensi PE, Behar A, de Champvallins MM,et al. Effects of a purified micronized 
flavonoid fraction on capillary filtration in diabetic patients. Diabet Med. 1996 
Oct;13(10):882-8. [PMID: 8911782]
19. Valensi P, Behar A. Clinical implications of impaired microcirculation. Int Angiol. 
1995 Sep;14(3 Suppl 1):26-31. [PMID: 8919261]
20. Behar A, Valensi P, de Champvallins M, et al. Capillary filtration and lymphatic 
resorption in diabetes. Application to the pharmacodynamic activity of Daflon 
500 mg. Int Angiol. 1989 Oct-Dec;8(4 Suppl):27-9. [PMID: 2632646]
21. Buckshee K, Takkar D, Aggarwal N. Micronized flavonoid therapy in internal 
hemorrhoids of pregnancy. Int J Gynaecol Obstet. 1997 May;57(2):145-51. 
[PMID: 9184951]
22. Cospite M. Double-blind, placebo-controlled evaluation of clinical activity and 
safety of Daflon 500 mg in the treatment of acute hemorrhoids. Angiology. 1994 
Jun;45(6 Pt 2):566-73. [PMID: 8203789]
23. Pari L, Srinivasan S. Antihyperglycemic effect of diosmin on hepatic key 
enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced 
diabetic rats. Biomed Pharmacother. 2010 Sep;64(7):477-81. [PMID: 20362409]
24. Srinivasan S, Pari L. Ameliorative effect of diosmin, a citrus flavonoid against 
streptozotocin-nicotinamide generated oxidative stress induced diabetic rats. 
Chem Biol Interact. 2012 Jan 5;195(1):43-51. [PMID: 22056647]
Additional references available upon request
Instructions/How to Use: Take one capsule twice per day. 


VEIN AWAY  is a well-researched citrus flavonoid that has been utilized for 
decades to support healthy capillary and vein function as well as healthy 
microcirculation throughout the body. Diosmin fundamentally helps maintain 
the structure and function of the circulatory system, especially vein strength 
and competence.
[1]
 The most promising research results come from a 
micronized purified flavonoid fraction comprising 450 mg of diosmin and 
50 mg of hesperidin (hesperidin is a precursor to diosmin). This is the same 
ratio and dose found in eacvVEIN AWAY capsule. The process of micronization 
(reducing particle size to less than two micrometers in diameter) improves 
diosmin absorption.*
[2]
Micronized purified flavonoid fraction (MPFF) appears to support vein health 
by prolonging the normal effect that the catecholamine norepinephrine has 
on the vessel wall; and this, therefore, promotes venous tone.
[3]
 Research 
also suggests that MPFF affects the synthesis of prostaglandins and free 
radicals, as well as leukocyte activation, trapping, and migration. Ultimately 
MPFF supports antioxidant systems and the body’s normal response to 
inflammation.*
[4-7]
Pharmacological and clinical studies suggest that MPFF—on its own and 
in conjunction with standard therapy—promotes normal lymph drainage, 
healthy capillary permeability, and favorable microcirculation. Multicenter, 
prospective, randomized, controlled studies document the effect of MPFF 
on maintaining healthy venous sufficiency.
[8]
 Two randomized, double-blind, 
placebo-controlled studies conducted over a two-month period demonstrated 
the venotropic nature of VEIN AWAY’s main component. Significant support of 
organic and functional parameters occurred along with significant support of 
venous hemodynamics.
[9]
 Some studies indicate that favorable results can be 
achieved within two hours of administration.*
[10]
A review of the literature suggests that health-related quality-of-life 
parameters were found to improve with the use of MPFF and were associated 
with the formula’s support of microcirculation and vein function.
[2]
 A singlecenter, double-blind, placebo-controlled study suggested that MPFF had 
a positive and protective effect on five study variables (red blood cell 
aggregation, red blood count, microcirculatory blood flux, and amplitude and 
frequency of vasomotion).
[11]
 A double-blind placebo-controlled trial of MPFF 
over a six-week period suggested that the formula, administered twice daily, 
significantly (p <0.001) supported capillary structure and health and was well 
tolerated throughout the study.
[12]
 A double-blind randomized study of 104 
subjects over a three-month period revealed that MPFF at various doses (500 
mg, 1000 mg, or 2000 mg per day) significantly supported transcutaneous 
oxygen pressure and venous competence.*
[13]
A meta-analysis of five prospective, randomized, controlled studies employing 
a total of 723 subjects suggested that MPFF promoted healthy tissue integrity 
when combined with conventional therapy (compression and local 
care).
[14,15]
 Similar results were obtained in a multicenter, double-blind, 
randomized, controlled study of 107 individuals.*
[16]
The worldwide RELIEF program (Reflux assEssment and quaLity of lIfe 
improvEment with micronized Flavonoids) studied the effects of MPFF on 
more than 5000 participants in 23 countries. A variety of subjects taking 
MPFF over a six-month period showed clinically significant improvements that 
indicated MPFF’s supportive effect on microcirculation and vein health and 
function. These improvements continued throughout the study.*
[17]
Placebo-controlled human trials support the use of MPFF for the maintenance 
of healthy metabolic parameters, microcirculation, fluid balance, lymph 
system function, and albumin retention.
[18-20]
 Results suggest that MPFF 
specifically supports normal capillary filtration, lymphatic albumin resorption, 
and fluid balance at the cellular level. Research on MPFF suggests that its 
positive effects may be extended to various parts of the body.*
[21,22]
Ongoing animal studies suggest that diosmin, the major component found in 
MPFF, significantly supports blood glucose and insulin levels already within 
the normal range and exerts favorable effects on maintaining healthy serum 
hemoglobin.
[23,24]
 Researchers hope to apply these benefits to maintaining 
healthy metabolic parameters in humans as well.*
Ingredients:
Micronized diosmin (from Citrus sinensis)(fruit)
   and hesperidin (from Citrus sinensis)(fruit) 500 MG PER CAPSULE
Cautions/Warnings:
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.


 
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